Ageing and stress

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Korenblit, Sivan

Developing new ways to overcome age-related proteostasis collapse, focusing on the UPR-ER...

Sar, Funda

My laboratory is working on the roles of miRNAs and LincRNAs in 1) stress responses, 2) protein homeostasis, and 3) ageing....

Söti, Csaba

We investigate the organization of various stress-responsive adaptation mechanisms that tailor life-span, immunity and learning / memory formation....

Sturzenbaum, Stephen

Some molecules are exclusively toxic to biological systems and others are essential for life; their interplay are vital drivers of well being, longevity and survival. Nevertheless, above certain threshold concentrations all compounds (including essential ones) become toxic....

Riedel, Christian

Lifespan is largely determined by the rate at which we age. In the Riedel laboratory we use the nematode Caenorhabditis Elegans as a model system to understand the pathways that can accelerate or impair this process. C. Elegans is ideal for ageing-related research, as it is technically well established, short-lived (allowing for lifespan as an easily measurable phenotype), and very responsive to alterations in its ageing-regulatory pathways....

Dalfó, Esther

My research is focused on the use of the nematode to study neurodegeneration. My two neurodegeneration topics are a) fatty acid accumulation defects and its role in neurodegeneration and b) contributing factors to the development of synucleinoapthies. ...

Wicky, Chantal

Transcription factors and chromatin modifiers are important in programming and reprogramming cell fate during development. We are investigating the function of the chromatin remodeler LET-418/Mi-2, which is part of at least two protein complexes, the NuRD and the MEC complexes involved in the development of the nematode Caenorhabditis elegans....

Schumacher, Björn

We are interested in the mechanisms through which genome instability causally contributes to cancer development and ageing. We are employing the nematode system to identify cellular and systemic response mechanisms to DNA damage....

Gross, Einav

In our lab we try to understand how oxygen homeostasis is regulated. We study this question at all levels; from the organismal to the molecular; we combine optogenetics, genetics, biochemical, and behavioral techniques....

Cohen, Ehud

Many human diseases emerge late in life. In our laboratory we study the mechanisms that link the aging process to late onset disorders that are associated with toxic protein aggregation (proteotoxicity) at the molecular, cell biological and organismal levels...

Casanueva, Olivia

Life expectancy is variable in many organisms, including laboratory strains of C. elegans that are isogenic. My group is focused on understanding the causes the underly the variability in lifespan. ...

Doitsidou, Maria

How is a nervous system made in a developing organism? Why do nerve cells die during aging or in cases of disease and how can we stop this from happening? ...

Schuster, Eugene

Recent ageing studies have revealed that ageing can be regulated and even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing....

Nollen, Ellen

Toxic aggregation-prone proteins are thought to play an important role in several age-related neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. ...

Muñoz, Manuel

Under unfavorable conditions, C. elegans responds with developmental changes, delay of reproductive period and increased longevity. We are interested in the genes and genetic pathways involved in the regulation of these decisions....