Funded by the Horizon 2020 Framework Programme
of the European Union

Author: Germano Cecere

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Postdoctoral Position in Epigenetic Inheritance and small RNAs at Institut Pasteur

The "Mechanisms of Epigenetic Inheritance" laboratory headed by Dr. Germano Cecere in the Department of Developmental and Stem Cell Biology at Institut Pasteur in Paris offers ERC-funded research opportunities for postdoctoral scientists with a strong interest in epigenetics and gene regulation. In our Laboratory, we study the role of small RNAs in epigenetic inheritance using the nematode C. elegans as a model system. We are integrating genetic, biochemical, and molecular biology tools with high-throughput genomic and proteomic approaches to achieve a molecular understanding of the epigenetic inheritance process in animals. The postdoc will work on understanding how small RNAs are generated and inherited through the gametes and how they transmit information from one generation to another. In addition, we will study the impact that these heritable molecules have on essential developmental processes and in transmitting the memory of past experiences, such as pathogen infections and other types of stresses. For more information on our research projects, visit our website and our recent publications. We are located at Institut Pasteur in Paris, which has a long-standing history of excellence in science and provides an outstanding international and multicultural scientific environment with experts in the fields of molecular, developmental, and computational biology. In addition, our Institute has excellent state-of-the-art core facilities, including proteomics, high throughput sequencing, and imaging technologies. Qualifications We are looking for highly passionate and motivated candidates holding a Ph.D. degree in Biochemistry, Molecular Biology, or any related area of Life Science. Candidates with a strong background in biochemistry, molecular and RNA biology, generation and/or analysis of next-generation sequencing, mass spectrometry, or quantitative microscopy are especially encouraged to apply. Previous experience with the C. elegans model would be an asset but not essential. Successful applicants are expected to have demonstrated the ability to work independently, have good organizational skills, work in an interdisciplinary team, and manage multiple tasks. English is our working language. Knowledge of French is not required. We offer An ERC consolidator grant funds the position for at least three years, and the salary will follow the guidelines for Postdoctoral fellowships of the Institut Pasteur. The candidates will benefit from technical and conceptual training, mentorship, and career development. The candidates will have the responsibility and freedom to shape, lead, and present their research projects. Our Laboratory is committed to maintaining a diverse and inclusive environment and promoting underrepresented scientists, trainees, and staff. Application details Applicants should submit the following information (PDF file formats preferred): 1. Curriculum vitae with contact information of at least two referees. 2. List of all publications (including pre-prints). 3. Motivation letter explaining past research experiences, your career goals, and motivation to join our laboratory and research programs. Applications should be sent by email to: The first round of evaluation will be concluded by March 15th, 2022, and only the selected candidates will be notified of the interview process. The starting date is flexible but ideally in Spring/Summer 2022....

Full-time indeterminate Research Technician position at Institut Pasteur

The Cecere Laboratory at Insitut Pasteur in Paris is looking for a Research Technician (Full-time indeterminate position) to join their Team in studying the mechanisms underlying epigenetic inheritance in animals. They use the nematode Caenorhabditis elegans to investigate the role of small non-coding RNAs in transmitting epigenetic information across generations. As a Research Technician, you would assist investigators in research activities and carry out assigned laboratory duties according to standard and specified procedures. In addition, you will be in charge of lab management responsibilities, including the maintenance of the worm collection, database of reagents, and equipment maintenance. Specific Requirements: • Molecular biology techniques, including DNA, RNA, protein extraction and purifications, PCR and molecular cloning. • C. elegans maintenance, crossing, and genotyping. • C. elegans transgenesis, including microinjection and screening of transgenic animals. • Basic microscopy manipulation skills. • Strong motivation, commitment, and ability to work independently as well as in a Team. • Excellent organizational skills. • Good oral and written command of English. • Basic knowledge of French is preferred. Qualifications: • Degree in Life Sciences (BSc or equivalent, or a higher degree) • Considerable prior laboratory work experience with C. elegans or similar model organisms. Ideally the candidate will also have experience in one of the following techniques: • Creation of transgenic C. elegans strains by CRISPR and/or MosSCI • Preparation and quantification of libraries for illumina sequencing (ex. RNA-seq) Environment: The candidates will benefit from training in a vibrantly intellectual and collaborative international environment. The expertise of our Team is wide-ranging and complementary, including many genome-wide sequencing methods (small RNA seq, RNA-seq, GRO-seq, CLIP-seq, Ribo-seq), biochemistry and proteomics, and imaging techniques. Applications, including CV and cover letter, should be sent by April 15th, 2019 to: Please, visit our website to know more about our research projects...