Funded by the Horizon 2020 Framework Programme
of the European Union

CELLS

Exciting Post doc opportunity to study the role of RNA pol III in longevity.

Applications are invited for an independent, forward thinking postdoctoral research fellow with a passion for ageing biology. The research in the Tullet laboratory aims to understand how transcription underpins the plasticity of adult physiology and lifespan in the nematode worm C. elegans. We are interested in a range of components of the eukaryotic transcriptional apparatus, from basal transcriptional machinery (see Filer et al. 2017 Nature) to specific transcription factors (Tullet et al. 2017 Ageing Cell and Tullet et al., 2008) and their role in adult physiology, health and lifespan. The laboratory is part of the School of Biosciences at the University of Kent. www.jennytulletlab.com This BBSRC-funded project aims to elucidate the molecular mechanisms whereby partial inhibition of RNA polymerase III can extend lifespan in the worm. The long-term aim of this work is to ensure human health and wellbeing throughout the life course. The project will be conducted in collaboration with Dr Nazif Alic (University College London) and Prof. Colin Selman (University of Glasgow). https://jobs.kent.ac.uk/vacancy.aspx?ref=STM-025-19...

Full-time indeterminate Research Technician position at Institut Pasteur

The Cecere Laboratory at Insitut Pasteur in Paris is looking for a Research Technician (Full-time indeterminate position) to join their Team in studying the mechanisms underlying epigenetic inheritance in animals. They use the nematode Caenorhabditis elegans to investigate the role of small non-coding RNAs in transmitting epigenetic information across generations. As a Research Technician, you would assist investigators in research activities and carry out assigned laboratory duties according to standard and specified procedures. In addition, you will be in charge of lab management responsibilities, including the maintenance of the worm collection, database of reagents, and equipment maintenance. Specific Requirements: • Molecular biology techniques, including DNA, RNA, protein extraction and purifications, PCR and molecular cloning. • C. elegans maintenance, crossing, and genotyping. • C. elegans transgenesis, including microinjection and screening of transgenic animals. • Basic microscopy manipulation skills. • Strong motivation, commitment, and ability to work independently as well as in a Team. • Excellent organizational skills. • Good oral and written command of English. • Basic knowledge of French is preferred. Qualifications: • Degree in Life Sciences (BSc or equivalent, or a higher degree) • Considerable prior laboratory work experience with C. elegans or similar model organisms. Ideally the candidate will also have experience in one of the following techniques: • Creation of transgenic C. elegans strains by CRISPR and/or MosSCI • Preparation and quantification of libraries for illumina sequencing (ex. RNA-seq) Environment: The candidates will benefit from training in a vibrantly intellectual and collaborative international environment. The expertise of our Team is wide-ranging and complementary, including many genome-wide sequencing methods (small RNA seq, RNA-seq, GRO-seq, CLIP-seq, Ribo-seq), biochemistry and proteomics, and imaging techniques. Applications, including CV and cover letter, should be sent by April 15th, 2019 to: cecerelab.openpositions@gmail.com Please, visit our website www.cecerelab.com to know more about our research projects...

Postdoctoral positions in the Ciosk lab, University of Oslo, Norway

We seek outstanding candidates interested in molecular mechanisms regulating body fat and/or stress adaptation. Our lab is at the University of Oslo, the oldest and largest university in Norway. Oslo is the country’s largest city, attractively located between the Oslofjord and forested hills. The city has an abundance of world-class architecture, museums, restaurants and shopping. For more information and to apply see: Postdoc: https://www.jobbnorge.no/en/available-jobs/job/165082/postdoctoral-research-fellowship-in-body-fat-regulation-cellular-stress Researcher: https://www.jobbnorge.no/en/available-jobs/job/165098/researcher-in-body-fat-regulation-cellular-stress ...

Post-doctoral position – Institut Jacques Monod PARIS – Pintard lab

Deciphering the role of the mitotic kinase Plk1 in Nuclear Envelope Breakdown We are looking for a highly motivated and team oriented postdoctoral candidate to work on the role and the regulation of the Polo-like kinase during mitotic entry using the early C. elegans embryo as model system. The Polo-like kinase Plk1 is an evolutionarily conserved serine-threonine kinase that plays a critical role during mitosis. Plk1 regulates mitotic entry, centrosomes maturation, spindle assembly, chromosomes segregation and cytokinesis. Plk1 activity must be tightly regulated, in space and time, as defect in Plk1 regulation has drastic consequences. Plk1 is overexpressed in numerous cancer types and this overexpression is associated with a poor prognosis for the patients. Despite considerable progress, how Plk1 activation is regulated remains only partially elucidated. Our objectives are i) to identify the mechanism regulating Plk1 activity in space and time, ii) define its role in mitosis and iii) develop novel Plk1 pathway inhibitors with anti-cancer properties. In this context, the candidate will focus on the role of Plk1 in nuclear envelope breakdown. Our group is part of the Institut Jacques Monod (https://www.ijm.fr) which is housed in a new building of 1800 square meters, located on the new campus of the Paris left bank urban project. The Institute Jacques Monod is one of the main public centers for fundamental research in biology in the Paris area and offers a state-of-the-art research environment. Financing is available for 12 months with the possibility for renewal but the candidate is expected to apply for its own funding with the support of the laboratory. The candidate is expected to hold a PhD, with no or max. 2 years of postdoctoral experience and with a solid background in Cell Biology/Molecular Biology and/or Biochemistry with at least one first author publication in a peer-reviewed journal from his/her PhD work. lnterested candidates should send their CV including research interests and contact details of two referees in a single pdf file to lionel.pintard@ijm.fr. Priority will be given to applications received before June 15th, but the position will remain open until a suitable candidate has been found. References: • Martino, L., Morchoisne-Bolhy, S., Cheerambathur, D. K., Van Hove, L., Dumont, J., Joly, N., Desai, A., Doye, V., and Pintard, L. (2017). Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans. Dev Cell 43, 157-171.e7. • Thomas, Y., Cirillo, L., Panbianco, C., Martino, L., Tavernier, N., Schwager, F., Van Hove, L., Joly, N., Santamaria, A., Pintard, L., and Gotta, M. (2016). Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells. Cell Rep 15, 510-518. • Tavernier, N., Noatynska, A., Panbianco, C., Martino, L., Van Hove, L., Schwager, F., Léger, T., Gotta, M., and Pintard, L. (2015). Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos. J Cell Biol 208, 661-669. ...

Announcing the GENIE workshop: The molecular and cellular basis of plasticity in sensory processing

COST BM1408 is organizing a new workshop: The molecular and cellular basis of plasticity in sensory processing. The aim of this workshop is to discuss and exchange ideas on neural circuit plasticity and techniques to interrogate circuits in C. elegans. Discussions will be kept informal, highlighting pros and cons of the different approaches to investigate sensory processing and behaviour as well as alternative interpretations of current models of plasticity. An important focus of the meeting will be to get the participants to interact and learn about each other’s work with the goal to foster collaborations. For details, visit the meeting page here....