Konstantinos Palikaras
Investigating the role of mitophagy in the cellular and organismal homeostasis....
Investigating the role of mitophagy in the cellular and organismal homeostasis....
Mechanisms of extracellular vesicle release and uptake in early embryonic development....
Our research focuses on the molecular mechanisms of necrotic cell death and neurodegeneration, the interplay between cellular metabolism and ageing, the mechanisms of sensory transduction and integration by the nervous system, and the development of novel genetic tools for biomedical research....
My research is focused on the use of the nematode to study neurodegeneration. My two neurodegeneration topics are a) fatty acid accumulation defects and its role in neurodegeneration and b) contributing factors to the development of synucleinoapthies. ...
We are interested in the symbiosis between Wolbachia endosymbionts and onchocercidae, a family of parasitic nematodes causing debilitating filariasis in tropical areas....
How is a nervous system made in a developing organism? Why do nerve cells die during aging or in cases of disease and how can we stop this from happening? ...
Recent ageing studies have revealed that ageing can be regulated and even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing....
My group uses C. elegans to study the in vivo function of the versatile Nucleotide Excision Repair pathway and the impact of its deficiency on a whole organism....
The main goal of our group is to deeper understand the molecular mechanisms that underlay cell differentiation during development and cancer. We focus our research in pathways that regulate differential gene expression and how mutations on these pathways alter the transcriptional mechanism. ...
Severe mitochondria deficiency leads in humans to devastating degenerative disorders, but we and others found that mild reduction of mitochondrial function has pro-longevity effects. This indicates that cellular adaptation to mild metabolic stress can induce beneficial responses, ...