Funded by the Horizon 2020 Framework Programme
of the European Union

Cell fate specification

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Braendle, Christian

Understanding how environmental variation and genotype-environment interactions contribute to phenotypic variation is a central challenge in current biology. While the significance of phenotypic plasticity and genotype-by-environment interactions is widely recognized, we are still lacking an integrated mechanistic and evolutionary understanding of how gene-environment interactions shape development and how they impact evolutionary processes....

Delattre, Marie

We are working on mechanisms of spindle positioning and spindle elongation using a combination of molecular, evolutionnary and biophysical approaches in worm embryos....

Dupuy, Denis

We explore regulatory networks of several nematodes to get insights in the evolution process of these mechanisms: how are loss and/or duplication of genes affecting the functional dynamics? Just like comparative genomics has proven tremendously powerful for genome annotation, comparative systems biology should help us understand how complex systems are modified, at the molecular level, throughout evolution to create diversity while preserving their main emerging properties....

Rodrigues, Ana João

We are using C. elegans as a model organism to dissect the biological role of genes associated with neurodevelopmental disorders such as epilepsy, autism and mental retardation....

Tursun, Baris

Most differentiated cells are refractory to induced direct cell fate switches. We aim to identify mechanisms that regulate the reprogramming of cells by directly converting a specific cell fate such as an epithelial or intestinal cell into, e.g., neurons or muscle cells in vivo....

Boxem, Mike

We study the molecular mechanisms that underlie cell polarity using a combination of high-throughput protein interaction mapping approaches and in vivo studies using the model organism C. elegans....

Cabello, Juan

The main goal of our group is to deeper understand the molecular mechanisms that underlay cell differentiation during development and cancer. We focus our research in pathways that regulate differential gene expression and how mutations on these pathways alter the transcriptional mechanism. ...