We use C. elegans as the reference nematode to perform comparative studies in cell biology, developmental biology and genetics. We currently have projects on soma-to-germline transmission of information, evolution of aging, and evolution of sex determination...
In our lab we try to understand how oxygen homeostasis is regulated. We study this question at all levels; from the organismal to the molecular; we combine optogenetics, genetics, biochemical, and behavioral techniques....
We are interested in the symbiosis between Wolbachia endosymbionts and onchocercidae, a family of parasitic nematodes causing debilitating filariasis in tropical areas....
We are interesting in understanding the consequences of different reproductive systems to the population and quantitative genetics of adaptation to novel environments....
Life expectancy is variable in many organisms, including laboratory strains of C. elegans that are isogenic. My group is focused on understanding the causes the underly the variability in lifespan. ...
Recent ageing studies have revealed that ageing can be regulated and even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing....
We are using a worm, the tiny soil nematode Caenorhabditis elegans, as a model system to study nervous system development per se and also as it relates to humans....
Work is using a primarily quantitative genetic approach in the Caenorhabditis species to understand the control of variation in complex traits, particulary those involved in adaptation to differing environments....
The major research interest in my newly established laboratory concerns the relationship between genotype and developmental phenotypes and how the environment modifies this relationship....
To what extent is it possible to predict the phenotypic differences amongst individuals from their completely sequenced genomes? We use model organisms (particularly C. elegans) and computational analyses to understand when you can, and why you cannot, predict the biology of an individual from their genome sequence alone....
One of the main goals of developmental biology is to understand how the different cell types that constitute a multicellular organism are specified during its development....
Our lab is interested in understanding how neuronal diversity is established and maintained. We also aim to explore if this processes are linked to genetic association to mental disorders....
By comparing the genetic programs of different animals, at the molecular level, our research seeks to discover the principles by which evolution achieves this feat. Our lab at the Technion is composed of developmental, molecular, and computational biologists....
Sleep-like states occur in the life of almost every animal studied. While the function of waking is obvious, the function of sleep is unknown. Sleep has been suggested to serve a restorative function in the nervous system. Our lab is trying to understand the function and regulation of sleep by studying different model organisms. ...
Understanding how environmental variation and genotype-environment interactions contribute to phenotypic variation is a central challenge in current biology. While the significance of phenotypic plasticity and genotype-by-environment interactions is widely recognized, we are still lacking an integrated mechanistic and evolutionary understanding of how gene-environment interactions shape development and how they impact evolutionary processes....