Akay, Alper
We study RNA modifications and their role in germ cell proliferation and differentiation. ...
We study RNA modifications and their role in germ cell proliferation and differentiation. ...
The use of transgenic Caenorhabditis elegans and gene expression analysis to understand Endocrine Disrupting Chemicals (EDCs) toxicity and Danube Delta bio-monitoring...
We investigate the regulation of chromatin function and gene expression in C. elegans....
The main objective of our research programme is to understand chromatin function and gene regulation....
My laboratory is working on the roles of miRNAs and LincRNAs in 1) stress responses, 2) protein homeostasis, and 3) ageing....
Some molecules are exclusively toxic to biological systems and others are essential for life; their interplay are vital drivers of well being, longevity and survival. Nevertheless, above certain threshold concentrations all compounds (including essential ones) become toxic....
Lifespan is largely determined by the rate at which we age. In the Riedel laboratory we use the nematode Caenorhabditis Elegans as a model system to understand the pathways that can accelerate or impair this process. C. Elegans is ideal for ageing-related research, as it is technically well established, short-lived (allowing for lifespan as an easily measurable phenotype), and very responsive to alterations in its ageing-regulatory pathways....
My research is focused on the use of the nematode to study neurodegeneration. My two neurodegeneration topics are a) fatty acid accumulation defects and its role in neurodegeneration and b) contributing factors to the development of synucleinoapthies. ...
Transcription factors and chromatin modifiers are important in programming and reprogramming cell fate during development. We are investigating the function of the chromatin remodeler LET-418/Mi-2, which is part of at least two protein complexes, the NuRD and the MEC complexes involved in the development of the nematode Caenorhabditis elegans....
We are interested in the symbiosis between Wolbachia endosymbionts and onchocercidae, a family of parasitic nematodes causing debilitating filariasis in tropical areas....
Our lab is located within a Hospital, which implies a biomedical orientation. We have two main interests: characterise function of genes whose orthologs has been relates to disease and cancer...
Life expectancy is variable in many organisms, including laboratory strains of C. elegans that are isogenic. My group is focused on understanding the causes the underly the variability in lifespan. ...
How is a nervous system made in a developing organism? Why do nerve cells die during aging or in cases of disease and how can we stop this from happening? ...
Recent ageing studies have revealed that ageing can be regulated and even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing....
We are using a worm, the tiny soil nematode Caenorhabditis elegans, as a model system to study nervous system development per se and also as it relates to humans....