My research is focused on the use of the nematode to study neurodegeneration. My two neurodegeneration topics are a) fatty acid accumulation defects and its role in neurodegeneration and b) contributing factors to the development of synucleinoapthies. ...
We are interested in the symbiosis between Wolbachia endosymbionts and onchocercidae, a family of parasitic nematodes causing debilitating filariasis in tropical areas....
Many human diseases emerge late in life. In our laboratory we study the mechanisms that link the aging process to late onset disorders that are associated with toxic protein aggregation (proteotoxicity) at the molecular, cell biological and organismal levels...
Life expectancy is variable in many organisms, including laboratory strains of C. elegans that are isogenic. My group is focused on understanding the causes the underly the variability in lifespan. ...
Recent ageing studies have revealed that ageing can be regulated and even more surprising is that many of the classic signaling pathways that have been exhaustively studied for many years are involved in the regulation of ageing....
The major research interest in my newly established laboratory concerns the relationship between genotype and developmental phenotypes and how the environment modifies this relationship....
My principal interest is the development of therapeutic strategies against amyloid-related pathologies using a variety of approaches including molecular biology, biochemical and biophysical analysis, and neuropathology....
Using C. elegans we are investigating how animals respond to the presence of pathogenic microorganisms. Animals, including humans, use two main strategies to defend themselves; the best characterised is the immune response but behavioural changes also play an important role in defence. ...
The maintenance of the redox homeostasis is critical for the survival of all organisms and its alterations underlay many human pathologies. The thioredoxin and glutaredoxin systems are two of the major system involved in the maintenance of the redox homeostasis....
We use C. elegans to understand the relationship between animals, nutrition and microbes. We have found that inhibition of E. coli folate synthesis increases C. elegans lifespan and we are investigating how this works and if it is applicable to the mammalian gut....