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Plasticity

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Muñoz, Manuel

Under unfavorable conditions, C. elegans responds with developmental changes, delay of reproductive period and increased longevity. We are interested in the genes and genetic pathways involved in the regulation of these decisions....

Ciosk, Rafal

I have a general interest in elucidating the molecular mechanisms controlling cell fate maintenance and reprogramming. We focus on the germline-soma dichotomy, elucidating both cytoplasmic and nuclear determinants controlling the commitment to the germ cell fate and the reprograming to pluripotency....

Pocock, Roger

My research focuses on how the diversity of fates and morphologies of the nervous system are generated....

Poulin, Gino

The main interest of the Poulin lab is to understand how signalling events occurring in the extracellular space can produce a response inside the cell to impact on the chromatin structure. This can release the transcriptional machinery for activation or prevent its engagement for repression....

Barkoulas, Michalis

The major research interest in my newly established laboratory concerns the relationship between genotype and developmental phenotypes and how the environment modifies this relationship....

Bertrand, Vincent

In both vertebrates and invertebrates, postmitotic neurons are often generated by asymmetric divisions of neuronal progenitors such as neural stem cells. This general mechanism used to build the nervous system raises two important questions : how are these asymmetric divisions coordinated in space and how do the daughter cells acquire different fates....

Braendle, Christian

Understanding how environmental variation and genotype-environment interactions contribute to phenotypic variation is a central challenge in current biology. While the significance of phenotypic plasticity and genotype-by-environment interactions is widely recognized, we are still lacking an integrated mechanistic and evolutionary understanding of how gene-environment interactions shape development and how they impact evolutionary processes....

Delattre, Marie

We are working on mechanisms of spindle positioning and spindle elongation using a combination of molecular, evolutionnary and biophysical approaches in worm embryos....

Dupuy, Denis

We explore regulatory networks of several nematodes to get insights in the evolution process of these mechanisms: how are loss and/or duplication of genes affecting the functional dynamics? Just like comparative genomics has proven tremendously powerful for genome annotation, comparative systems biology should help us understand how complex systems are modified, at the molecular level, throughout evolution to create diversity while preserving their main emerging properties....

Rodrigues, Ana João

We are using C. elegans as a model organism to dissect the biological role of genes associated with neurodevelopmental disorders such as epilepsy, autism and mental retardation....

Tursun, Baris

Most differentiated cells are refractory to induced direct cell fate switches. We aim to identify mechanisms that regulate the reprogramming of cells by directly converting a specific cell fate such as an epithelial or intestinal cell into, e.g., neurons or muscle cells in vivo....

Miranda-Vizuete, Antonio

The maintenance of the redox homeostasis is critical for the survival of all organisms and its alterations underlay many human pathologies. The thioredoxin and glutaredoxin systems are two of the major system involved in the maintenance of the redox homeostasis....

Aguilaniu, Hugo

Our lab works about the genetic of the aging process. More specifically, we study the links between nutrition, reproduction, lipid metabolism and lifespan. Indeed, all of these processes are closely intertwined, yet little is known about the way they interconnect....