Pokrzywa, Wojciech
The goal of our research is to understand both, spatiotemporal control of protein quality control activity as well as substrate processing....
The goal of our research is to understand both, spatiotemporal control of protein quality control activity as well as substrate processing....
My research aims to understand the causative role of protein misfolding in neurodegenerative diseases...
Developing new ways to overcome age-related proteostasis collapse, focusing on the UPR-ER...
Our research is focused on defining how stem cells maintain proteostasis and identify novel mechanisms to delay the age=associated decline of proteostasis...
Our lab aims to identify these regulatory mechanisms and to evaluate how physiological protein aggregation impacts the health of the organism during aging and in the context of disease....
Owing to improved medical care and treatment our society is rapidly aging. As a result, age-related diseases are also on the rise. These have a strong impact on the aging individual as well as on our society. Age-related maladies involve multiple and often distinct organ systems....
Differentiation, developmental processes and environmental changes challenge the integrity of the proteome in every eukaryotic cell. Proteostasis is maintained by re-folding or degradation of unfolded and damaged proteins and enables cellular function, organismal development and viability....