Most differentiated cells are refractory to induced direct cell fate switches. We aim to identify mechanisms that regulate the reprogramming of cells by directly converting a specific cell fate such as an epithelial or intestinal cell into, e.g., neurons or muscle cells in vivo. C .elegans as a model organism provides straightforward genetic tractability and the visualization of cell fate conversions instantly in living animals. High-throughput forward genetic screens as well as RNAi knock-downs can be easily applied and allow a systematic interrogation of the entire genome for factors that might play a role in regulating direct reprogramming of cell types.