Gene regulation and cell fate decision in C. elegans
Most differentiated cells are refractory to induced direct cell fate switches. We aim to identify mechanisms that regulate the reprogramming of cells by directly converting a specific cell fate such as an epithelial or intestinal cell into, e.g., neurons or muscle cells in vivo. C .elegans as a model organism provides straightforward genetic tractability and the visualization of cell fate conversions instantly in living animals. High-throughput forward genetic screens as well as RNAi knock-downs can be easily applied and allow a systematic interrogation of the entire genome for factors that might play a role in regulating direct reprogramming of cell types.
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