The role of the chromatin remodelers in the development of a multicellular organism
Transcription factors and chromatin modifiers are important in programming and reprogramming cell fate during development. We are investigating the function of the chromatin remodeler LET-418/Mi-2, which is part of at least two protein complexes, the NuRD and the MEC complexes involved in the development of the nematode Caenorhabditis elegans. Using genetic and biochemical approaches, we found that LET-418/Mi-2 interacts with other chromatin remodelers to regulate development and maintain germ cell fate. Furthermore, we recently uncovered a new function for LET-418/Mi-2 in the regulation of normal lifespan and stress resistance, which is conserved in plant and fly. We think that LET-418/Mi-2 is in the center of important developmental decisions and, in this context, it may also regulate resource allocation to control lifespan and stress resistance in the worm.
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