Understanding how chromatin and nuclear organization respond to environmental stress. What are the implications not only for cells but also for an organism?
In recent years, it has emerged that epigenetic modifications link the environment and the genome. A striking example is the metabolic state of the cell. In fact, enzymes that modify chromatin do so using metabolic intermediates as cofactors, therefore the nutritional state of an organism can impact on its epigenome. Despite such a tight connection, how cells and organisms respond to and “protect” their epigenomes in face of fluctuations of metabolites remain largely unknown. Our group aims at understanding how environmental stress, particularly nutrients availability, affects the state, spatial compartmentalization and function of chromatin using C. elegans as a model organism.
Start Lab in 2020