Understanding widespread protein aggregation with age.
Protein misfolding and aggregation is a pathological hallmark of neurodegenerative diseases. Recently, it has been shown that widespread protein insolubility and aggregation occurs during normal aging, in the absence of disease. This discovery gives us the unprecedented opportunity to dissect the intrinsic cellular machineries responsible for preventing protein aggregation without using ectopically expressed human disease-associated proteins. Our lab aims to identify these regulatory mechanisms and to evaluate how physiological protein aggregation impacts the health of the organism during aging and in the context of disease.
Start Lab in 2011