Regulation of the molecular motor dynein by co-factors and adapters.
Cytoplasmic dynein 1 (dynein), a multi-protein complex of 1.2 megadaltons, is the predominant microtubule minus-end-directed motor in animals. Dynein participates in a wide range of essential cellular activities, ranging from the transport of proteins, mRNA, and vesicles to nuclear migration and cell division. Our group is interested in the regulatory mechanisms that give rise to dynein’s functional diversity. We use live-cell fluorescence microscopy, genetics, and biochemical approaches in the roundworm Caenorhabditis elegans and mammalian cultured cells to study the roles and molecular mechanisms of co-factors and adapters that associate with dynein to modulate localization, interaction with cargo, and motor activity.
Start Lab in 2012