Chromatin Remodelling and Telomere Maintenance
My research focusses on chromatin dynamics from local chromatin structure to global nuclear organization and how this regulates cellular processes. In particular, I am interested in ATP-dependent chromatin remodeling enzymes and telomere maintenance. My goal is to understand how the cross-talk between these systems is regulated within a developmental context and to uncover novel targets and regulators of chromatin remodeling enzymes. This is done by combining forward genetic analysis with in vitro biochemistry to obtain mechanistic insight into novel chromatin remodeling enzymes and the means by which they affect telomere function.
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