Quantitative Developmental Biology
My research group uses a quantitative, physics-inspired approach to study problems in developmental biology, focusing on C. elegans. The aim of the research is to elucidate how living organisms build their bodies during development in a robust manner, despite the considerable underlying stochastic variability on the molecular level. The current research in the lab focuses on stochastic cell fate decisions and spatial pattern formation. We address these questions using novel experimental techniques, such as single molecule Fluorescence In Situ Hybridization (smFISH), quantitative timelapse microscopy and microfabrication, in combination with quantitative data analysis and mathematical modeling.
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