The long-term health of all metazoan cells is inextricably linked to protein quality control. An imbalance in protein homeostasis (proteostasis) can result in severe molecular damage to the cell, directly leading to tissue pathology and to enhanced susceptibility to diseases not only including metabolic disease and neurodegeneration, but also cancer and immunodeficiency. Our group aims to uncover the complex mechanisms of the proteostasis network, strategies to cope with protein aggregates and its changes during development and with the progression of aging.