The current research activities can be divided into five main areas:

• Environmental stress, thiol-based redox signaling, thiol-based redox gene regulation and redox homeostasis
• Other glutathione-related enzymes
• Regulation of translation and protein synthesis in Caenorhabditis elegans focussing on the 1+ translational frameshift of the antizyme
• The secretome of parasitic nematodes: Analysis of host-parasite cross-talk
• The UFM1 cascade is a posttranslational modification system highly conserved in most multicellular organisms. UFM1 is implicated in various human diseases. We are utilizing C. elegans as a model system to understand the cellular functions of the UFM1 cascade.