The development of drug resistance
Our project meets the current challenge posed by resistance to antiparasitic drugs, which emerges as a critical public health and economic problem. We have been working since several years on the pharmacology and toxicity of anthelmintic drugs used to treat parasitic nematodes. I then developed C. elegans as a model nematode for investigating the adaptation to anthelmintics and changes that occurred through acute and chronic exposure to the drugs. We evaluate the adaptation of worms that occur during a drug selection pressure process, and identify changes that are linked with resistance phenotype. The overall objective of this project is to understand the mechanisms underlying the development of drug tolerance in nematodes and to identify the key factors involved in susceptibility against these anthelmintic drugs. Several aspects are under investigation: (i) the role of the worm detoxification network in the adaptive mechanisms in response to drug exposure; (ii) the impact of this adaptation on the physiology of worms (life history traits, cross-tolerance…); (iii) the regulatory pathways of main metabolic functions and (iv) the link between expression of genes associated with xenobiotic metabolism and transport, drug pharmacokinetic in worms the selection of resistance.
Start Lab in 2013