The molecular mechanisms of cell polarity.
My group uses a combination of systems biology approaches, systematic experimental manipulation, and live-cell imaging to study the process of cell polarization. Cell polarity is critical to animal development and tissue functioning, and defects in polarity are an important factor in the development of cancer and other diseases. Cell polarity is mediated by a complex network of interactions between several groups of proteins located at the cell surface. Using C. elegans as a model system, we aim to understand three aspects of polarity:
Start Lab in 2008