We are interested in understanding the role of mitochondria in environemtnally induced neuronal aging and diseases
Severe mitochondria deficiency leads in humans to devastating degenerative disorders, but we and others found that mild reduction of mitochondrial function has pro-longevity effects. This indicates that cellular adaptation to mild metabolic stress can induce beneficial responses, which if identified may represent promising candidates to prevent or delay the development of age-associated disorders thus ultimately extending healthy lifespan. We exploits C. elegans as a powerful genetic and screening tool to unravel molecular mechanisms of mitochondrial-stress control of longevity and of mitochondria-associated diseases, with special attention revolved to the crosstalk between genetic and environmental interventions.
Start Lab in 2012