The focus of my lab is to investigate molecular mechanisms behind diseases characterized with genetic or acquired mitochondria dysfunction such as inherited mitochondrial disorders, obesity and non-alcoholic fatty liver disease. The research aims at understanding the role of polyamine metabolism and NAD+-dependent enzymes, sirtuins and poly(ADP-ribose) polymerases in the regulation of mitochondrial function in normal and diseased states. The overall goal is to develop novel treatments for both inherited mitochondrial disorders and aging related metabolic diseases.