Elucidating the molecular mechanisms controlling cell fate maintenance and reprogramming and Regulation of mRNA in animal development
We focus on the germline-soma dichotomy, elucidating both cytoplasmic and nuclear determinants controlling the commitment to the germ cell fate and the reprograming to pluripotency. A long-term goal is to identify genes and pathways that could restore pluripotency to differentiated cells, which has potential biomedical implications. In addition to this main goal, my lab investigates the function of conserved RNA-binding proteins in translational regulation during development and stress. In our work, we combine genetics with molecular, biochemical, and genomic approaches.
Start Lab in