The aim of our research is to understand how cellular physiology can be controled by basic molecular and cellular pathways regulating the biology of two-pore domain potassium channels (K2P). By allowing the outward flow of potassium ions, these channels maintain the cell’s resting membrane potential and counteract depolarization. Thus, K2P channels play a central role in the control of neuronal excitability. However, little is known about the genes and specific cellular pathways that regulate the function of K2P channels. Our goal is to use genetic strategies in the model nematode C. elegans to identify and characterize the factors that regulate this important family of ion channels.